20240053270. PATHOGENIC SUSCEPTIBILITY ASSESSMENT BASED ON AUTOFLUORESENCE simplified abstract (Adiuvo Diagnostics Private Limited)

PATHOGENIC SUSCEPTIBILITY ASSESSMENT BASED ON AUTOFLUORESENCE

Organization Name

Adiuvo Diagnostics Private Limited

Inventor(s)

Bala Pesala of Siruseri Chennai (IN)

Geethanjali Radhakrishnan of Siruseri Chennai (IN)

John King of Siruseri Chennai (IN)

PATHOGENIC SUSCEPTIBILITY ASSESSMENT BASED ON AUTOFLUORESENCE - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240053270 titled 'PATHOGENIC SUSCEPTIBILITY ASSESSMENT BASED ON AUTOFLUORESENCE

Simplified Explanation

The abstract describes a method for assessing the susceptibility of a target pathogen based on autofluorescence features exhibited by the pathogen when subjected to excitation radiation.

• Sample containing target pathogen and target drug is obtained.
• Autofluorescence features of the sample are determined in response to excitation radiation.
• Features are analyzed using a susceptibility-detection model to determine pathogen's susceptibility to the drug.
• Model is trained using training autofluorescence features correlated with reference data on pathogen susceptibility/resistance.

Potential Applications:

• Rapid and accurate assessment of pathogen susceptibility to drugs.
• Personalized medicine for targeted treatment of infections.

Problems Solved:

• Overuse of broad-spectrum antibiotics.
• Delayed or ineffective treatment due to inaccurate susceptibility testing.

Benefits:

• Faster and more precise determination of effective treatment options.
• Reduced risk of antibiotic resistance development.
• Improved patient outcomes through tailored therapy.

Original Abstract Submitted

examples of assessing susceptibility of a target pathogen based on autofluorescence, are described. in an example, a sample containing a target pathogen and a predefined concentration of a target drug may be obtained. thereafter, autofluorescence features based on autofluorescence exhibited by the sample in response to the sample being subjected to excitation radiation, may be determined. once the autofluorescence features are determined, they may be analyzed based on a susceptibility-detection model to determine susceptibility of the target pathogen with respect to the target drug. in an example, the susceptibility-detection model is trained based on a training autofluorescence features correlated with reference data, in which the reference data includes information pertaining to susceptibility or resistance of a reference pathogen with respect to a reference drug.