20240051986. METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER simplified abstract (SUMITOMO CHEMICAL COMPANY, LIMITED)
Contents
METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER
Organization Name
SUMITOMO CHEMICAL COMPANY, LIMITED
Inventor(s)
Takuya Miyagawa of Oita-shi (JP)
Hideki Okumura of Oita-shi (JP)
METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER - A simplified explanation of the abstract
This abstract first appeared for US patent application 20240051986 titled 'METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER
Simplified Explanation
The present invention describes an efficient process for preparing a nucleic acid oligomer by effectively removing a protecting group from a hydroxy group in the nucleic acid oligomer. The invention also provides a method for preparing a specific nucleic acid oligomer by treating a nucleic acid oligomer with a fluoride ion under an atmosphere of an inert gas or inert gases with low oxygen concentration.
- The process efficiently removes a protecting group from a hydroxy group in a nucleic acid oligomer.
- The method allows for the preparation of a specific nucleic acid oligomer by treating it with a fluoride ion under specific conditions.
- The invention provides a simplified and effective approach to deprotecting hydroxy groups in nucleic acid oligomers.
Potential applications of this technology:
- Nucleic acid research: The efficient process for preparing nucleic acid oligomers can be used in various nucleic acid research applications, such as DNA sequencing, gene expression analysis, and genetic engineering.
- Therapeutics: The specific preparation of nucleic acid oligomers can be utilized in the development of nucleic acid-based therapeutics, including antisense oligonucleotides and RNA interference (RNAi) therapies.
- Diagnostics: The technology can be applied in diagnostic assays, such as nucleic acid amplification tests (NAATs) and polymerase chain reaction (PCR), for the detection and identification of specific nucleic acid sequences.
Problems solved by this technology:
- Inefficient deprotection: The invention addresses the problem of inefficient removal of protecting groups from hydroxy groups in nucleic acid oligomers, ensuring a more effective and reliable process.
- Specific oligomer preparation: The method solves the challenge of preparing specific nucleic acid oligomers by providing a controlled and precise treatment with a fluoride ion under specific atmospheric conditions.
Benefits of this technology:
- Improved efficiency: The process offers an efficient and streamlined approach to deprotecting hydroxy groups in nucleic acid oligomers, saving time and resources.
- Enhanced specificity: The method allows for the specific preparation of nucleic acid oligomers, ensuring the desired sequence is obtained with high accuracy.
- Versatility: The technology can be applied in various fields, including research, therapeutics, and diagnostics, providing a versatile solution for nucleic acid-related applications.
Original Abstract Submitted
the present invention provides an efficient process for preparing a nucleic acid oligomer, specifically a method for deprotecting a protecting group of hydroxy group in the nucleic acid oligomer effectively. the present invention provides also a process for preparing a nucleic acid oligomer represented by formula (4) which comprises contacting a nucleic acid oligomer represented by formula (3) with a fluoride ion under an atmosphere of an inert gas or inert gases containing 15% or less of oxygen concentration (wherein each definition of the groups described in the formula (3) and the formula (4) are the same as those described in the description).
