20240051975. NOVEL NAMPT ENZYME AGONIST AND PREPARATION AND USE THEREOF simplified abstract (Tsinghua University)

NOVEL NAMPT ENZYME AGONIST AND PREPARATION AND USE THEREOF

Organization Name

Tsinghua University

Inventor(s)

Gelin Wang of Beijing (CN)

Yefeng Tang of Beijing (CN)

Hong Yao of Beijing (CN)

Minghui Liu of Beijing (CN)

Leibo Wang of Beijing (CN)

Chenyu Li of Beijing (CN)

Ruoxi Zhang of Beijing (CN)

Yumeng Zu of Beijing (CN)

Chuo Wu of Beijing (CN)

Feifei Li of Beijing (CN)

Shuangquan Chen of Beijing (CN)

NOVEL NAMPT ENZYME AGONIST AND PREPARATION AND USE THEREOF - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240051975 titled 'NOVEL NAMPT ENZYME AGONIST AND PREPARATION AND USE THEREOF

Simplified Explanation

The present invention is a novel class of nampt enzyme agonists and their preparation and use. These agonists, represented by formulas I and II, have been screened from a chemical small molecule library and have shown good cytoprotective and anti-neurodegeneration effects in animal models.

• The invention provides a defined structure-activity relationship for the nampt agonist nat through multiple rounds of structure optimization.
• The patent lays the foundation for developing innovative drugs for anti-aging and neurodegenerative diseases.
• Enhancing nampt enzyme activity is shown to play an important role in neuroprotection.

Potential Applications:

• Development of innovative drugs for anti-aging and neurodegenerative diseases.
• Treatment and prevention of neurodegeneration.
• Cytoprotection in various cellular processes.

Problems Solved:

• Lack of effective drugs for anti-aging and neurodegenerative diseases.
• Limited understanding of the role of nampt enzyme activity in neuroprotection.
• Need for a defined structure-activity relationship for nampt agonists.

Benefits:

• Improved treatment options for anti-aging and neurodegenerative diseases.
• Enhanced understanding of the role of nampt enzyme activity in neuroprotection.
• Potential for developing targeted therapies for specific neurodegenerative conditions.

Original Abstract Submitted

the present invention provides a class of novel nampt enzyme agonist and preparation and use thereof, which has a structural formula as shown in formula i or formula ii. the present invention screens the nampt agonist nat from the chemical small molecule library, and the nat exhibits a good cytoprotective effect and a good anti-neurodegeneration effect in animal models of neurodegeneration. we studied the binding of nat to enzymes, and then carried out multiple rounds of structure optimization based on the chemical structure characteristics of nat and its enzyme activity properties, and obtained a relatively defined structure-activity relationship. the present patent not only lays the foundation for developing innovative drugs for anti-aging and neurodegenerative diseases, but also theoretically provides a proof-of-concept that enhancing nampt enzyme activity plays an important role in neuroprotection.