20240050442. TRIMEPRAZINE DERIVATIVES AND COMPOSITIONS COMPRISING THE SAME FOR TREATING A NEUROPSYCHIATRIC DISORDER simplified abstract (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE)

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TRIMEPRAZINE DERIVATIVES AND COMPOSITIONS COMPRISING THE SAME FOR TREATING A NEUROPSYCHIATRIC DISORDER

Organization Name

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor(s)

BARBARA Bardoni of NICE (FR)

THOMAS Maurin of ANTIBES (FR)

TRIMEPRAZINE DERIVATIVES AND COMPOSITIONS COMPRISING THE SAME FOR TREATING A NEUROPSYCHIATRIC DISORDER - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240050442 titled 'TRIMEPRAZINE DERIVATIVES AND COMPOSITIONS COMPRISING THE SAME FOR TREATING A NEUROPSYCHIATRIC DISORDER

Simplified Explanation

The present invention is about trimeprazine derivatives that can be used to treat neuropsychiatric disorders such as intellectual disability (ID), fragile X syndrome (FXS), autism spectrum disorders (ASD), and attention deficit hyperactivity disorder (ADHD). The invention also includes pharmaceutical compositions containing these derivatives.

  • Trimeprazine derivatives of formula (i) are used for treating neuropsychiatric disorders.
  • The specific disorders that can be treated include intellectual disability (ID), fragile X syndrome (FXS), autism spectrum disorders (ASD), and attention deficit hyperactivity disorder (ADHD).
  • The invention also includes pharmaceutical compositions that contain these trimeprazine derivatives.

Potential Applications

  • Treatment of intellectual disability (ID)
  • Treatment of fragile X syndrome (FXS)
  • Treatment of autism spectrum disorders (ASD)
  • Treatment of attention deficit hyperactivity disorder (ADHD)

Problems Solved

  • Lack of effective treatments for intellectual disability (ID)
  • Limited treatment options for fragile X syndrome (FXS)
  • Limited treatment options for autism spectrum disorders (ASD)
  • Limited treatment options for attention deficit hyperactivity disorder (ADHD)

Benefits

  • Provides a potential treatment option for intellectual disability (ID)
  • Offers a new approach for treating fragile X syndrome (FXS)
  • Provides a potential treatment option for autism spectrum disorders (ASD)
  • Offers a new approach for treating attention deficit hyperactivity disorder (ADHD)


Original Abstract Submitted

the present invention relates to trimeprazine derivatives of formula (i) for use for treating a neuropsychiatric disorder chosen among an intellectual disability (id), preferably fragile x syndrome (fxs), autism spectrum disorders (asd), and attention deficit hyperactivity disorder (adid). the invention also relates to pharmaceutical compositions for use comprising such derivatives.