20240044853. REPLACEABLE EMITTER ASSEMBLY FOR INTERFACING A SEPARATION COLUMN TO A MASS SPECTROMETER simplified abstract (THERMO HYPERSIL-KEYSTONE LLC)

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REPLACEABLE EMITTER ASSEMBLY FOR INTERFACING A SEPARATION COLUMN TO A MASS SPECTROMETER

Organization Name

THERMO HYPERSIL-KEYSTONE LLC

Inventor(s)

Brandon Howard Robson of Bellefonte PA (US)

Xuefei Sun of San Jose CA (US)

Xiaodong Liu of Cupertino CA (US)

REPLACEABLE EMITTER ASSEMBLY FOR INTERFACING A SEPARATION COLUMN TO A MASS SPECTROMETER - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240044853 titled 'REPLACEABLE EMITTER ASSEMBLY FOR INTERFACING A SEPARATION COLUMN TO A MASS SPECTROMETER

Simplified Explanation

The abstract of the patent application describes an electrospray emitter assembly that connects a separation column to a mass spectrometer. The assembly includes an emitter capillary with an inlet and outlet end, a fitting that can be connected to the separation column, and a stop with a through hole near the inlet end of the emitter. The through hole allows liquid to flow from the separation column to the emitter, where a voltage is applied to the liquid.

  • The invention is an electrospray emitter assembly for interfacing a separation column to a mass spectrometer.
  • The assembly includes an emitter capillary with an inlet and outlet end.
  • A fitting is coupled to the inlet end of the emitter and can be removably connected to the separation column.
  • A stop with a defined through hole is integrated near the inlet end of the emitter.
  • The through hole creates a path for liquid to flow from the separation column to the emitter.
  • A voltage is applied to the liquid entering the emitter.

Potential applications of this technology:

  • Mass spectrometry: The electrospray emitter assembly allows for the efficient transfer of separated analytes from a separation column to a mass spectrometer, enabling accurate analysis of complex samples.
  • Proteomics: The assembly can be used in proteomics research to identify and quantify proteins in biological samples, aiding in the understanding of disease mechanisms and drug discovery.
  • Metabolomics: By coupling the separation column to a mass spectrometer, the assembly can be used to analyze and identify small molecules in biological samples, providing insights into metabolic pathways and disease biomarkers.

Problems solved by this technology:

  • Efficient interface: The electrospray emitter assembly provides a reliable and efficient interface between a separation column and a mass spectrometer, ensuring the transfer of analytes without loss or contamination.
  • Voltage control: The application of voltage to the liquid entering the emitter allows for the generation of electrospray, which enhances ionization efficiency and sensitivity in mass spectrometry.
  • Compatibility: The assembly is designed to be easily connected and disconnected from the separation column, allowing for flexibility in experimental setups and easy maintenance.

Benefits of this technology:

  • Improved sensitivity: The electrospray emitter assembly enhances ionization efficiency, leading to improved sensitivity in mass spectrometry analysis.
  • Versatility: The assembly can be used with various separation techniques, such as liquid chromatography or capillary electrophoresis, making it adaptable to different analytical needs.
  • Easy maintenance: The removable fitting and integrated stop facilitate easy cleaning and maintenance of the assembly, ensuring reliable and consistent performance.


Original Abstract Submitted

an electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. an emitter capillary includes an inlet end and an outlet end. a fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column. a stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.

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