20240043938. BIOMARKER PANEL AND METHODS FOR DETECTING MICROSATELLITE INSTABILITY IN CANCERS simplified abstract (Biocartis NV)

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BIOMARKER PANEL AND METHODS FOR DETECTING MICROSATELLITE INSTABILITY IN CANCERS

Organization Name

Biocartis NV

Inventor(s)

Bram De Craene of Mechelen (BE)

Klaas Decanniere of Mechelen (BE)

Jan Van De Velde of Mechelen (BE)

Geert Maertens of Mechelen (BE)

BIOMARKER PANEL AND METHODS FOR DETECTING MICROSATELLITE INSTABILITY IN CANCERS - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240043938 titled 'BIOMARKER PANEL AND METHODS FOR DETECTING MICROSATELLITE INSTABILITY IN CANCERS

Simplified Explanation

The present invention is related to the field of cancer, specifically cancers with microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency. Examples of such cancers include colorectal, gastric, and endometrial tumors. The invention provides a novel diagnostic marker panel for analyzing MSI loci, along with methods and kits for using this panel to detect cancers with MSI and/or MMR- deficiency.

  • The invention is a diagnostic marker panel for analyzing MSI loci.
  • The panel can be used to detect cancers with MSI and/or MMR- deficiency.
  • The invention includes methods and kits for using the panel in cancer detection.

Potential applications of this technology:

  • Improved diagnosis and detection of cancers with MSI and/or MMR- deficiency.
  • Personalized treatment strategies for patients with these types of cancers.
  • Monitoring the effectiveness of cancer treatments targeting MSI and/or MMR- deficiency.

Problems solved by this technology:

  • Current methods for detecting cancers with MSI and/or MMR- deficiency may be complex and time-consuming.
  • The invention provides a simplified and efficient approach for analyzing MSI loci and detecting these types of cancers.

Benefits of this technology:

  • Early and accurate detection of cancers with MSI and/or MMR- deficiency.
  • Facilitates personalized treatment plans for patients.
  • Potential for improved patient outcomes and survival rates.


Original Abstract Submitted

the present invention generally relates to the field of cancer, in particular to cancers having microsatellite instability (msi) and/or mismatch repair (mmr-) deficiency. examples of such cancers include many colorectal, gastric, and endometrial tumors. accordingly, the present invention provides a novel diagnostic marker panel for analyzing msi loci, together with methods and kits of using said panel in the detection of cancers having microsatellite instability (msi) and/or mismatch repair (mmr-) deficiency.