20240043781. FIXED BED BIOREACTOR AND METHODS OF USING THE SAME simplified abstract (CORNING INCORPORATED)
Contents
FIXED BED BIOREACTOR AND METHODS OF USING THE SAME
Organization Name
Inventor(s)
Ann MeeJin Ferrie of Salem NH (US)
Vasiliy Nikolaevich Goral of Painted Post NY (US)
FIXED BED BIOREACTOR AND METHODS OF USING THE SAME - A simplified explanation of the abstract
This abstract first appeared for US patent application 20240043781 titled 'FIXED BED BIOREACTOR AND METHODS OF USING THE SAME
Simplified Explanation
The patent application describes a fixed-bed bioreactor system that includes a vessel with a media inlet, a media outlet, and an interior cavity. The interior cavity is in fluid communication with the media inlet and media outlet. Within the interior cavity, there is a cell culture substrate arranged in a packed-bed configuration. The cell culture substrate consists of multiple porous disks stacked together. The interior cavity is divided into a cell culture section and a spacer section, with the cell culture substrate defining the cell culture section. Each porous disk has a surface designed for cell culture.
- The patent application describes a fixed-bed bioreactor system with a vessel, media inlet, media outlet, and an interior cavity.
- The interior cavity contains a cell culture substrate in a packed-bed configuration.
- The cell culture substrate consists of multiple porous disks stacked together.
- The interior cavity is divided into a cell culture section and a spacer section.
- Each porous disk has a surface optimized for cell culture.
Potential Applications:
- Biomedical research and drug development: The fixed-bed bioreactor system can be used for cell culture and cultivation of cells for various biomedical research purposes, including drug development and testing.
- Tissue engineering: The system can be utilized for growing and cultivating tissue constructs for tissue engineering applications, such as regenerative medicine and organ transplantation.
- Bioproduction: The fixed-bed bioreactor system can be employed for large-scale production of biological products, such as therapeutic proteins, antibodies, and vaccines.
Problems Solved:
- Enhanced cell culture efficiency: The packed-bed configuration and stacked arrangement of porous disks provide a larger surface area for cell culture, allowing for higher cell density and improved productivity.
- Simplified operation: The fixed-bed design eliminates the need for continuous stirring or agitation, reducing complexity and minimizing the risk of cell damage.
- Scalability: The system can be easily scaled up for larger production volumes, making it suitable for industrial bioproduction.
Benefits:
- Increased productivity: The fixed-bed bioreactor system enables higher cell density and improved productivity compared to traditional bioreactor systems.
- Cost-effective: The simplified operation and scalability of the system contribute to cost-effectiveness in cell culture and bioproduction processes.
- Versatility: The system can be used for various cell culture applications, including research, tissue engineering, and bioproduction, making it a versatile tool in the field of biotechnology.
Original Abstract Submitted
a fixed-bed bioreactor system is provided that includes a vessel with a media inlet, a media outlet, and an interior cavity disposed between and in fluid communication with the media inlet and media outlet. the vessel further includes a cell culture substrate disposed in the interior cavity between the media inlet and the media outlet in a packed-bed configuration, the cell culture substrate including a plurality of porous disks in a stacked arrangement. the interior cavity includes a cell culture section and a spacer section, the cell culture substrate defining the cell culture section and the spacer section being disposed between the cell culture section and the media outlet, and each of the plurality of porous disks has a surface configured to culture cells thereon.
