20240026301. METHODS AND COMPOSITIONS FOR GENERATING ENDOTHELIAL CELLS FROM PLURIPOTENT STEM CELLS simplified abstract (Trailhead Biosystems Inc.)

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METHODS AND COMPOSITIONS FOR GENERATING ENDOTHELIAL CELLS FROM PLURIPOTENT STEM CELLS

Organization Name

Trailhead Biosystems Inc.

Inventor(s)

Angelica M. Gomes Ueltschy of Shaker Heights OH (US)

METHODS AND COMPOSITIONS FOR GENERATING ENDOTHELIAL CELLS FROM PLURIPOTENT STEM CELLS - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240026301 titled 'METHODS AND COMPOSITIONS FOR GENERATING ENDOTHELIAL CELLS FROM PLURIPOTENT STEM CELLS

Simplified Explanation

The patent application provides methods for generating CD31+VE−cadherin+KDR+ endothelial cells (ECs) using chemically-defined culture media. These methods can generate ECs from early mesoderm progenitors in as little as three days and from pluripotent stem cells in as little as five days. The application also includes information on the culture media, isolated cell populations, and kits used in the methods.

  • Methods for generating CD31+VE−cadherin+KDR+ endothelial cells (ECs) are provided.
  • The methods use chemically-defined culture media.
  • ECs can be generated from early mesoderm progenitors in as little as three days.
  • ECs can also be generated from pluripotent stem cells in as little as five days.
  • The application includes information on the culture media, isolated cell populations, and kits used in the methods.

Potential Applications:

  • Regenerative medicine: The generated ECs can be used for tissue engineering and regenerative medicine applications.
  • Drug discovery: The ECs can be used for testing the efficacy and safety of new drugs targeting endothelial cells.
  • Disease modeling: The ECs can be used to study various diseases and develop new therapies.

Problems Solved:

  • Time-consuming and complex methods for generating ECs are simplified.
  • The methods provide a faster and more efficient way to generate ECs from different cell sources.
  • The chemically-defined culture media eliminate the need for animal-derived components, reducing the risk of contamination and ethical concerns.

Benefits:

  • Faster generation of ECs allows for quicker research and development in various fields.
  • The chemically-defined culture media provide a more controlled and reproducible environment for cell culture.
  • The methods can be easily adapted for different cell sources and applications.


Original Abstract Submitted

methods for generating cd31+ve−cadherin+kdr+ endothelial cells (ecs) are provided using chemically-defined culture media that allow for generating ecs from early mesoderm progenitors in as little as three days and from pluripotent stem cells in as little as five days. culture media, isolated cell populations and kits are also provided.

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