20240019360. METHOD AND SYSTEM FOR ANALYST OF CRYSTALS AND CRYSTALLIZATION simplified abstract (PROTEIN DYNAMIC SOLUTIONS, INC.)

METHOD AND SYSTEM FOR ANALYST OF CRYSTALS AND CRYSTALLIZATION

Organization Name

PROTEIN DYNAMIC SOLUTIONS, INC.

Inventor(s)

Belinda Pastrana-rios of Wakefield MA (US)

METHOD AND SYSTEM FOR ANALYST OF CRYSTALS AND CRYSTALLIZATION - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240019360 titled 'METHOD AND SYSTEM FOR ANALYST OF CRYSTALS AND CRYSTALLIZATION

Simplified Explanation

The disclosed patent application describes methods and systems for analyzing compounds in a crystalline state or undergoing crystallization. It introduces two-dimensional correlation (2DCOS) and co-distribution analysis (2DCDS) plots that can be generated and analyzed. These plots help establish a sequential order of events by showing asynchronous peaks. Positive cross peaks that correlate with auto peaks associated with aggregation can be identified. By referencing the auto peaks, the regions of the molecule most perturbed can be discerned, indicating a driver for the crystallization state. The patent application also discusses how changes in auto peaks in synchronous plots for different stages of crystallization can provide information about the dynamics of the process from amorphous to crystalline state.

• Methods and systems for analyzing compounds in a crystalline state or undergoing crystallization are disclosed.
• Two-dimensional correlation (2DCOS) and co-distribution analysis (2DCDS) plots are introduced for analysis.
• Asynchronous plots help establish a sequential order of events.
• Positive cross peaks correlated with auto peaks associated with aggregation can be identified.
• Auto peaks can be referenced to determine the regions of the molecule most perturbed, indicating a driver for crystallization.
• Changes in auto peaks in synchronous plots for different stages of crystallization provide information about the dynamics of the process.

Potential Applications:

• Pharmaceutical industry: Analyzing the crystallization process of drugs to optimize formulation and stability.
• Material science: Studying the crystallization behavior of materials for improved properties and performance.
• Chemical synthesis: Monitoring and optimizing the crystallization process of chemical compounds.

Problems Solved:

• Lack of a comprehensive method for analyzing compounds in a crystalline state or undergoing crystallization.
• Difficulty in determining the sequential order of events during crystallization.
• Limited understanding of the dynamics and drivers of the crystallization process.

Benefits:

• Improved understanding of the crystallization process, leading to better control and optimization.
• Enhanced formulation and stability of drugs through optimized crystallization.
• Improved properties and performance of materials through controlled crystallization.
• Efficient chemical synthesis through optimized crystallization processes.

Original Abstract Submitted

the disclosure relates to methods and systems for the analysis of compounds in a crystalline state and/or undergoing crystallization. two-dimensional correlation (2dcos) and co-distribution analysis (2 dcds) analysis plots can be generated and analyzed. asynchronous plots can aid in establishing a sequential order of events. positive cross peaks that correlate with auto peaks associated with aggregation can be identified. the auto peaks can be referenced to quickly discern the regions of the molecule most perturbed, which would indicate a driver for the crystallization state of the molecule. one can define which functional group types (e.g., region) are most perturbed (positive, intense auto peak) and observe how the different auto peaks begin to have greatest intensity change. these changes in auto peaks in the synchronous plots for the different stages of crystallization can provide information as to the dynamics of the process from amorphous to crystalline state.