20240017082. CLASSICAL CONDITIONING OF NEUROMODULATION WITH SYNCHRONIZED MUSICAL STIMULATION simplified abstract (The Florida State University Research Foundation, Inc.)

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CLASSICAL CONDITIONING OF NEUROMODULATION WITH SYNCHRONIZED MUSICAL STIMULATION

Organization Name

The Florida State University Research Foundation, Inc.

Inventor(s)

Kevin Johnson of Tallahassee FL (US)

Frank Andrew Kozel of Tallahassee FL (US)

Jayne Standley of Tallahassee FL (US)

CLASSICAL CONDITIONING OF NEUROMODULATION WITH SYNCHRONIZED MUSICAL STIMULATION - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240017082 titled 'CLASSICAL CONDITIONING OF NEUROMODULATION WITH SYNCHRONIZED MUSICAL STIMULATION

Simplified Explanation

The patent application describes a device that combines transcranial magnetic stimulation (TMS) with synchronized audio stimulation to produce neurostimulation effects. The device generates a magnetic field waveform at a specific brain region, such as the motor cortex, and synchronizes it with an audio waveform that includes rhythm, harmonic elements, or melodic elements. This combination of TMS and audio stimulation can evoke neurostimulation effects through classical conditioning.

  • The device includes a transcranial magnetic stimulation (TMS) device that generates a localized magnetic field waveform at a specific brain region.
  • An acoustic controller is included in the device, which generates an audio waveform synchronized to the magnetic field waveform.
  • The brain region targeted by the device can be the motor cortex of a patient.
  • The device can produce neurostimulation effects through acoustic stimulation, such as music, paired with synchronized transcranial magnetic stimulation output.
  • The device can be used to extend the effects of neuromodulation, reducing the need for in-patient visits, reducing battery life demand of implanted devices, and improving the patient experience with achieving benefits.

Potential Applications:

  • Treatment of neurological disorders: The device can be used to treat various neurological disorders by providing synchronized TMS and audio stimulation to specific brain regions.
  • Rehabilitation: The device can aid in the rehabilitation of patients with motor impairments by targeting the motor cortex and providing synchronized stimulation.
  • Mental health: The device may have applications in the treatment of mental health conditions, such as depression or anxiety, by modulating brain activity through synchronized TMS and audio stimulation.

Problems Solved:

  • Burden of in-patient visits: The device can reduce the need for frequent in-patient visits for procedural neurostimulation by extending the effects of neuromodulation.
  • Battery life demand: By combining TMS with audio stimulation, the device can reduce the battery life demand of implanted devices by utilizing external audio sources.
  • Patient experience: The device improves the patient experience by providing neurostimulation effects through listening to music, which is more natural and enjoyable compared to traditional neurostimulation sensations.

Benefits:

  • Enhanced treatment outcomes: The synchronized TMS and audio stimulation can potentially enhance treatment outcomes by combining two different modalities of neurostimulation.
  • Improved patient compliance: The use of music or audio stimulation can improve patient compliance and engagement with the treatment.
  • Reduced side effects: By utilizing synchronized audio stimulation, the device may reduce potential side effects associated with traditional neurostimulation techniques.


Original Abstract Submitted

a device may include a transcranial magnetic stimulation (tms) device configured to generate a localized magnetic field waveform at a brain region. a device may include an acoustic controller configured to generate an audio waveform having at least one of rhythm, harmonic element, or melodic element synchronized to the localized magnetic field waveform. in various implementations, the brain region is a motor cortex of a patient. the device can evoke or produce neurostimulation effects through acoustic stimulation (e.g., music) through classical (or pavlovian) conditioning paired in combination with synchronized transcranial magnetic stimulation output. the device can be used to extend the effects of neuromodulation, thus reducing the burden of in-patient visits (for procedural neurostimulation), reducing battery life demand of implanted devices, or simply improving the patient experience with achieving benefits (i.e., by listening to music versus unnatural sensory sensations with neurostimulation).

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