20240011883. DETERMINING INTERACTIONS BETWEEN CELLULAR BODIES AND A FUNCTIONALIZED WALL SURFACE simplified abstract (LUMICKS CA HOLDING B.V.)

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DETERMINING INTERACTIONS BETWEEN CELLULAR BODIES AND A FUNCTIONALIZED WALL SURFACE

Organization Name

LUMICKS CA HOLDING B.V.

Inventor(s)

Jelle Van Der Horst of Amsterdam (NL)

DETERMINING INTERACTIONS BETWEEN CELLULAR BODIES AND A FUNCTIONALIZED WALL SURFACE - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240011883 titled 'DETERMINING INTERACTIONS BETWEEN CELLULAR BODIES AND A FUNCTIONALIZED WALL SURFACE

Simplified Explanation

The patent application describes a method for determining the interaction between cellular bodies and a functionalized wall surface. Here is a simplified explanation of the abstract:

  • The method involves obtaining a sequence of images that represent the manipulation of cellular bodies in a holding space with a functionalized wall surface.
  • The functionalized wall surface is designed to bind the cellular bodies by applying a force.
  • The locations of pixel groups in the images are tracked, where each pixel group represents a cellular body.
  • The locations of the pixel groups in the images define the trajectory of the cellular body relative to the functionalized wall surface.
  • One or more speed values of the cellular body at different locations along the trajectory are determined, and these speed values are higher than zero.
  • The classification of whether the cellular body is attached to the functionalized wall surface is based on the one or more speed values and at least one threshold speed value.

Potential Applications of this Technology:

  • Cell manipulation and sorting in biological research and medical applications.
  • Development of microfluidic devices for cell analysis and diagnostics.
  • Study of cellular adhesion and interaction with different surfaces.
  • Investigation of cellular behavior in response to external forces.

Problems Solved by this Technology:

  • Provides a method to determine if cellular bodies are attached to a functionalized wall surface.
  • Enables tracking and analysis of cellular movement and attachment.
  • Facilitates the study of cellular behavior in controlled environments.

Benefits of this Technology:

  • Allows for precise manipulation and control of cellular bodies.
  • Provides insights into cellular adhesion and interaction mechanisms.
  • Enables the development of new techniques for cell analysis and diagnostics.
  • Facilitates research in fields such as tissue engineering and regenerative medicine.


Original Abstract Submitted

a method for determining interaction between cellular bodies and a functionalized wall surface comprises: obtaining a sequence of images representing manipulating cellular bodies in a holding space having a functionalized wall surface configured to bind the cellular bodies that includes applying a force; tracking locations of pixel groups in respective images out of the sequence of images, each pixel group in the images representing a cellular body out of the cellular bodies, the locations in the respective images defining a trajectory of the cellular body moving relative to the functionalized wall surface; determining one or more speed values of the cellular body at one or more locations of the trajectory, the one or more speed values being higher than zero; and, classifying that the cellular body is attached to the functionalized wall surface based on the one or more speed values and at least one threshold speed value.

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