20240010980. NATURAL KILLER CELLS WITH ENHANCED ACTIVITY simplified abstract (THE REGENTS OF THE UNIVERSITY OF CALIFORNIA)

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NATURAL KILLER CELLS WITH ENHANCED ACTIVITY

Organization Name

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor(s)

Dan S. Kaufman of La Jolla CA (US)

Kenta Yamamoto of La Jolla CA (US)

NATURAL KILLER CELLS WITH ENHANCED ACTIVITY - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240010980 titled 'NATURAL KILLER CELLS WITH ENHANCED ACTIVITY

Simplified Explanation

The abstract of the patent application describes the invention of engineered immune cells, specifically natural killer (NK) cells, that have an inactivating mutation for a gene called a-disintegrin-and-metalloproteinase 17 (ADAM 17). These ADAM17-deficient immune cells are produced from stem cells, including induced pluripotent stem cells (iPSCs), and have enhanced antibody-dependent cellular cytotoxicity (ADCC). The patent application also includes pharmaceutical compositions comprising these engineered immune cells, as well as methods for making and using them.

  • Engineered immune cells, particularly NK cells, are created with an inactivating mutation in the ADAM 17 gene.
  • The ADAM17-deficient immune cells are derived from stem cells, including iPSCs.
  • The engineered immune cells exhibit enhanced ADCC, which is the ability to kill target cells using antibodies.
  • Pharmaceutical compositions containing these engineered immune cells are disclosed.
  • Methods for producing the engineered immune cells and pharmaceutical compositions are provided.
  • The invention has potential applications in immunotherapy and cancer treatment.
  • The technology solves the problem of limited efficacy of immune cells in killing target cells.
  • The engineered immune cells overcome the limitations of endogenous ADAM 17 activity, leading to enhanced ADCC.
  • The benefits of this technology include improved immune cell function and potential for more effective cancer treatments.


Original Abstract Submitted

engineered immune cells, optionally natural killer (nk) cells, comprising an inactivating mutation for an endogenous a-disintegrin-and-metalloproteinase 17 (adam 17) gene. adam17-deficient immune cells produced from stem cells, optionally, induced pluripotent stem cells (ipscs), having enhanced antibody-dependent cellular cytotoxicity (adcc). pharmaceutical compositions comprising said engineered immune cells. methods for making the engineered immune cell and pharmaceutical compositions, and methods of use are provided.

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