20240010972. PACKED BED BIOREACTORS WITH CONTROLLED ZONAL POROSITY simplified abstract (CORNING INCORPORATED)

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PACKED BED BIOREACTORS WITH CONTROLLED ZONAL POROSITY

Organization Name

CORNING INCORPORATED

Inventor(s)

Vasiliy Nikolaevich Goral of Painted Post NY (US)

PACKED BED BIOREACTORS WITH CONTROLLED ZONAL POROSITY - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240010972 titled 'PACKED BED BIOREACTORS WITH CONTROLLED ZONAL POROSITY

Simplified Explanation

The patent application describes a system for culturing cells using a packed-bed cell culture matrix and bioreactor. Here is a simplified explanation of the abstract:

  • The system includes a cell culture vessel with an inlet, an outlet, and an interior reservoir connected to the inlet and outlet.
  • A cell culture matrix is placed in the reservoir, which has a substrate material with pores for cell adherence.
  • A permeability zone is present in a part of the cell culture matrix, with higher permeability than the rest of the matrix.
  • The permeability zone has an opening in the substrate that is larger than the diameter of any of the pores.

Potential applications of this technology:

  • Biomedical research: The system can be used for culturing cells in a controlled environment, allowing researchers to study cell behavior and develop new treatments.
  • Tissue engineering: The cell culture matrix can be used to create artificial tissues and organs for transplantation or drug testing.
  • Biopharmaceutical production: The system can be used to produce large quantities of cells for the production of biopharmaceuticals.

Problems solved by this technology:

  • Enhanced cell growth: The permeability zone allows for better nutrient and oxygen supply to the cells, promoting their growth and viability.
  • Improved cell adhesion: The substrate material of the cell culture matrix provides a structurally defined surface for cells to adhere to, improving their attachment and functionality.

Benefits of this technology:

  • Increased cell yield: The system's design and the presence of the permeability zone enhance cell growth, leading to higher cell yields.
  • Enhanced cell functionality: The structurally defined substrate material promotes proper cell adhesion, allowing cells to maintain their natural functions.
  • Scalability: The system can be scaled up for large-scale cell culture production, making it suitable for industrial applications.


Original Abstract Submitted

a packed-bed cell culture matrix and bioreactor system for culturing cells is provided. the system includes a cell culture vessel having an inlet, an outlet, and an interior reservoir fluidly connected to and disposed between the inlet and the outlet. a cell culture matrix is disposed in the reservoir, the cell culture matrix having a structurally defined substrate with a substrate material defining a plurality of pores, and the substrate material is for adhering cells thereto. a permeability zone is located in a portion of the cell culture matrix, the at least one permeability zone having a higher permeability than a standard permeability of the cell culture matrix outside of the permeability zone. the permeability zone has an opening in the substrate, where the opening is larger than a diameter of any of the plurality of pores.

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