20240009320. BIOCOMPATIBLE ORGANOGEL MATRICES FOR PREPARATION OF A DRUG DELIVERY DEPOT simplified abstract (DEPUY SYNTHES PRODUCTS, INC.)

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BIOCOMPATIBLE ORGANOGEL MATRICES FOR PREPARATION OF A DRUG DELIVERY DEPOT

Organization Name

DEPUY SYNTHES PRODUCTS, INC.

Inventor(s)

Charles Florek of West Chester PA (US)

Eric Cozzone of Glenmoore PA (US)

David A. Armbruster of West Chester PA (US)

BIOCOMPATIBLE ORGANOGEL MATRICES FOR PREPARATION OF A DRUG DELIVERY DEPOT - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240009320 titled 'BIOCOMPATIBLE ORGANOGEL MATRICES FOR PREPARATION OF A DRUG DELIVERY DEPOT

Simplified Explanation

The present disclosure is about an organogel drug depot that can be used in non-sterile environments and applied to non-sterile open wound sites. It is also applicable for delivering an active agent to surgical sites, such as orthopedic implant sites.

  • The organogel drug depot is a system for preparing a drug delivery matrix.
  • It includes an organogel matrix made of an organogelator and a biocompatible organic solvent.
  • The matrix also contains solid particles of an active agent.
  • The system includes a container with at least one wall that can hold the organogel matrix and active agent particles.
  • There is a heating component in the system that can supply heat to the container.

Potential applications of this technology:

  • Non-sterile wound care: The organogel drug depot can be used to deliver drugs to non-sterile open wound sites, providing localized treatment.
  • Surgical site drug delivery: It can be used to deliver drugs to surgical sites, such as orthopedic implant sites, enhancing post-operative recovery and reducing the risk of infection.

Problems solved by this technology:

  • Non-sterile environment: The organogel drug depot allows for drug delivery in non-sterile environments, expanding the range of treatment options.
  • Controlled drug release: The organogel matrix provides a controlled release of the active agent, ensuring optimal drug delivery to the target site.

Benefits of this technology:

  • Versatility: The organogel drug depot can be used in various non-sterile environments and for different applications, making it a versatile drug delivery system.
  • Localized treatment: The depot allows for localized drug delivery, minimizing systemic side effects and maximizing the therapeutic effect at the target site.
  • Controlled release: The organogel matrix provides a controlled release of the active agent, ensuring sustained and effective drug delivery over time.


Original Abstract Submitted

the present disclosure is directed to an organogel drug depot for use in a non-sterile environment and application to a non-sterile open wound site. the present disclosure is also directed to an organogel drug depot for use in delivering an active agent to a surgical site, such as an implant site, for instance an orthopedic implant site. in a further embodiment, there is disclosed a system for preparing an organogel drug depot including an organogel matrix comprising an organogelator and a biocompatible organic solvent, an active agent comprising solid particles, a container including at least one wall having an outer surface and defining a volume capable of containing the organogel matrix and active agent solid particles, and a heating component configured to contact the outer surface and supply an amount of heat to the container.

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