18235184. PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES simplified abstract (THE REGENTS OF THE UNIVERSITY OF CALIFORNIA)
Contents
- 1 PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES
- 1.1 Organization Name
- 1.2 Inventor(s)
- 1.3 PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES - A simplified explanation of the abstract
- 1.4 Simplified Explanation
- 1.5 Potential Applications
- 1.6 Problems Solved
- 1.7 Benefits
- 1.8 Potential Commercial Applications
- 1.9 Possible Prior Art
- 1.10 How does this technology compare to existing methods for modifying amino acid residues in proteins?
- 1.11 What are the limitations of this technology in terms of scalability and practical application?
- 1.12 Original Abstract Submitted
PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES
Organization Name
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor(s)
Timothy J. Deming of Los Angeles CA (US)
Eric G. Gharakhanian of Los Angeles CA (US)
PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES - A simplified explanation of the abstract
This abstract first appeared for US patent application 18235184 titled 'PREPARATION OF FUNCTIONAL HOMOCYSTEINE RESIDUES IN POLYPEPTIDES AND PEPTIDES
Simplified Explanation
The methodology developed in the patent application involves transforming methionine residues into homocysteine derivatives through alkylations and demethylations at low pH. This process allows for the selective conversion of methionine residues into alkyl homocysteine residues, tolerating many functional groups.
- Methionine residues can undergo alkylation reactions at low pH.
- Sulfonium ions are formed as a result of these reactions.
- Sulfonium ions can be selectively demethylated to yield alkyl homocysteine residues.
- The process is compatible with various functional groups.
Potential Applications
The technology could be applied in the development of new drugs, protein engineering, and bioconjugation techniques.
Problems Solved
This technology provides a method for selectively modifying methionine residues in proteins, which can be challenging using traditional methods.
Benefits
The methodology offers a precise and efficient way to transform methionine residues into homocysteine derivatives, expanding the possibilities for protein modification.
Potential Commercial Applications
The technology could be valuable in the pharmaceutical industry for drug development and in biotechnology for protein engineering applications.
Possible Prior Art
One possible prior art could be the use of chemical modifications to alter amino acid residues in proteins, but the specific transformation of methionine residues into homocysteine derivatives may be novel.
Unanswered Questions
How does this technology compare to existing methods for modifying amino acid residues in proteins?
The article does not provide a direct comparison with other methods commonly used for modifying amino acid residues in proteins.
What are the limitations of this technology in terms of scalability and practical application?
The article does not address the scalability of the methodology or potential challenges in implementing it on a larger scale for industrial applications.
Original Abstract Submitted
Methodology was developed for transformation of methionine residues into homocysteine derivatives. Methionine residues can undergo alkylation reactions at low pH to yield sulfonium ions, which can then be selectively demethylated to give alkyl homocysteine residues. This process tolerates many functional groups.
