18156511. SELECTIVELY CONTROLLABLE CLEAVABLE LINKERS simplified abstract (MICROSOFT TECHNOLOGY LICENSING, LLC)
Contents
SELECTIVELY CONTROLLABLE CLEAVABLE LINKERS
Organization Name
MICROSOFT TECHNOLOGY LICENSING, LLC
Inventor(s)
Karin Strauss of Seattle WA (US)
Bichlien Hoang Nguyen of Seattle WA (US)
SELECTIVELY CONTROLLABLE CLEAVABLE LINKERS - A simplified explanation of the abstract
This abstract first appeared for US patent application 18156511 titled 'SELECTIVELY CONTROLLABLE CLEAVABLE LINKERS
Simplified Explanation
The patent application describes selectively controllable cleavable linkers that can be used to attach polymers to a solid substrate and enable their release. These linkers can be selectively cleaved by changing local conditions such as activating electrodes, exposing to light, heating, or applying chemicals. Enzymatically-cleavable linkers can be designed to respond to different enzymes for selective cleavage. The linkers can also be used to attach protecting groups to growing polymers, which can be selectively removed to enable growth of specific polymers.
- Selectively controllable cleavable linkers for attaching polymers to a solid substrate
- Cleavage of linkers can be controlled by changing local conditions
- Local conditions can be changed by activating electrodes, exposing to light, heating, or applying chemicals
- Enzymatically-cleavable linkers can be designed to respond to different enzymes for selective cleavage
- Linkers can be used to attach protecting groups to growing polymers
- Protecting groups can be selectively removed by cleavage of the linkers for growth of specific polymers
Potential Applications
- Controlled release of specific polymers from a solid substrate
- Selective growth of specific polymers by removing protecting groups
Problems Solved
- Enables controlled release of polymers from a solid substrate
- Facilitates selective growth of specific polymers
Benefits
- Provides a versatile and controllable method for attaching and releasing polymers
- Allows for selective growth of specific polymers
- Offers flexibility in designing and controlling polymer-based systems
Original Abstract Submitted
Selectively controllable cleavable linkers include electrochemically-cleavable linkers, photolabile linkers, thermolabile linkers, chemically-labile linkers, and enzymatically-cleavable linkers. Selective cleavage of individual linkers may be controlled by changing local conditions. Local conditions may be changed by activating electrodes in proximity to the linkers, exposing the linkers to light, heating the linkers, or applying chemicals. Selective cleaving of enzymatically-cleavable linkers may be controlled by designing the sequences of different sets of the individual linkers to respond to different enzymes. Cleavable linkers may be used to attach polymers to a solid substrate. Selective cleavage of the linkers enables release of specific polymers from the solid substrate. Cleavable linkers may also be used to attach protecting groups to the ends of growing polymers. The protecting groups may be selectively removed by cleavage of the linkers to enable growth of specific polymers.
