17643324. INTEGRATED SILICON PLATFORM FOR ELECTRONIC BIOSENSORS simplified abstract (INTERNATIONAL BUSINESS MACHINES CORPORATION)
Contents
INTEGRATED SILICON PLATFORM FOR ELECTRONIC BIOSENSORS
Organization Name
INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor(s)
Sufi Zafar of Briarcliff Manor NY (US)
Benjamin Hardy Wunsch of Mt. Kisco NY (US)
INTEGRATED SILICON PLATFORM FOR ELECTRONIC BIOSENSORS - A simplified explanation of the abstract
This abstract first appeared for US patent application 17643324 titled 'INTEGRATED SILICON PLATFORM FOR ELECTRONIC BIOSENSORS
Simplified Explanation
The patent application describes a structure and method for analyzing a sample fluid using a microfluidic system and a semiconductor device. Here are the key points:
- The structure includes a silicon substrate with a microfluidic system that receives a sample fluid and prepares an analyte solution.
- The analyte solution is received by a reservoir containing a sensing surface, which is electrically connected to a semiconductor device.
- The components of the structure include a sample fluid receiver, a sample fluid preparation component, a CRISPR system for cleaving a reporter species, a sorting component for separating the cleaved reporter species, a cavity for receiving the analyte solution, and a sensing surface.
- The sensing surface detects electrical signals induced by reaction events in the analyte solution.
Potential applications of this technology:
- Medical diagnostics: The structure can be used to analyze biological samples for the presence of specific target sequences, allowing for the detection of diseases or genetic mutations.
- Environmental monitoring: The structure can be used to analyze water or air samples for the presence of contaminants or pollutants.
- Food safety testing: The structure can be used to analyze food samples for the presence of harmful bacteria or toxins.
Problems solved by this technology:
- Rapid analysis: The microfluidic system allows for quick and efficient processing of the sample fluid, reducing the time required for analysis.
- High sensitivity: The sensing surface can detect small electrical signals induced by reaction events, allowing for the detection of low concentrations of analytes.
- Specificity: The CRISPR system can specifically cleave the reporter species when the sample fluid contains a target sequence, ensuring accurate and reliable analysis.
Benefits of this technology:
- Miniaturization: The use of a silicon substrate and microfluidic system allows for the integration of multiple components into a compact and portable structure.
- Cost-effective: The use of semiconductor devices and microfluidic systems can reduce the cost of analysis compared to traditional methods.
- Automation: The structure can be easily automated, allowing for high-throughput analysis of multiple samples.
Original Abstract Submitted
A structure, apparatus, and method are disclosed. A silicon substrate with a microfluidic system that receives a sample fluid and prepares an analyte solution received by a reservoir containing a sensing surface is electrically connected to a semiconductor device. The structure includes a component for receiving a sample fluid, a component for preparing the sample fluid, a CRISPR system for cleaving a reporter species when the sample fluid contains a target sequence, a sorting component for separating the cleaved reporter species from the sample fluid and the CRISPR products, a cavity for receiving an analyte solution containing the cleaved reporter species, and a sensing surface in the cavity. The sensing surface detects electrical signals induced by reaction events in the analyte solution.
