View source for 20240044853. REPLACEABLE EMITTER ASSEMBLY FOR INTERFACING A SEPARATION COLUMN TO A MASS SPECTROMETER simplified abstract (THERMO HYPERSIL-KEYSTONE LLC)

=REPLACEABLE EMITTER ASSEMBLY FOR INTERFACING A SEPARATION COLUMN TO A MASS SPECTROMETER=


==Organization Name==

[[:Category:THERMO HYPERSIL-KEYSTONE LLC|THERMO HYPERSIL-KEYSTONE LLC]]


[[Category:THERMO HYPERSIL-KEYSTONE LLC]]

==Inventor(s)==

[[:Category:Brandon Howard Robson of Bellefonte PA (US)|Brandon Howard Robson of Bellefonte PA (US)]][[Category:Brandon Howard Robson of Bellefonte PA (US)]]

[[:Category:Xuefei Sun of San Jose CA (US)|Xuefei Sun of San Jose CA (US)]][[Category:Xuefei Sun of San Jose CA (US)]]

[[:Category:Xiaodong Liu of Cupertino CA (US)|Xiaodong Liu of Cupertino CA (US)]][[Category:Xiaodong Liu of Cupertino CA (US)]]

==REPLACEABLE EMITTER ASSEMBLY FOR INTERFACING A SEPARATION COLUMN TO A MASS SPECTROMETER - A simplified explanation of the abstract==


This abstract first appeared for US patent application 20240044853 titled 'REPLACEABLE EMITTER ASSEMBLY FOR INTERFACING A SEPARATION COLUMN TO A MASS SPECTROMETER

==Simplified Explanation==

The abstract of the patent application describes an electrospray emitter assembly that connects a separation column to a mass spectrometer. The assembly includes an emitter capillary with an inlet and outlet end, a fitting that can be connected to the separation column, and a stop with a through hole near the inlet end of the emitter. The through hole allows liquid to flow from the separation column to the emitter, where a voltage is applied to the liquid.

* The invention is an electrospray emitter assembly for interfacing a separation column to a mass spectrometer.
* The assembly includes an emitter capillary with an inlet and outlet end.
* A fitting is coupled to the inlet end of the emitter and can be removably connected to the separation column.
* A stop with a defined through hole is integrated near the inlet end of the emitter.
* The through hole creates a path for liquid to flow from the separation column to the emitter.
* A voltage is applied to the liquid entering the emitter.

Potential applications of this technology:

* Mass spectrometry: The electrospray emitter assembly allows for the efficient transfer of separated analytes from a separation column to a mass spectrometer, enabling accurate analysis of complex samples.
* Proteomics: The assembly can be used in proteomics research to identify and quantify proteins in biological samples, aiding in the understanding of disease mechanisms and drug discovery.
* Metabolomics: By coupling the separation column to a mass spectrometer, the assembly can be used to analyze and identify small molecules in biological samples, providing insights into metabolic pathways and disease biomarkers.

Problems solved by this technology:

* Efficient interface: The electrospray emitter assembly provides a reliable and efficient interface between a separation column and a mass spectrometer, ensuring the transfer of analytes without loss or contamination.
* Voltage control: The application of voltage to the liquid entering the emitter allows for the generation of electrospray, which enhances ionization efficiency and sensitivity in mass spectrometry.
* Compatibility: The assembly is designed to be easily connected and disconnected from the separation column, allowing for flexibility in experimental setups and easy maintenance.

Benefits of this technology:

* Improved sensitivity: The electrospray emitter assembly enhances ionization efficiency, leading to improved sensitivity in mass spectrometry analysis.
* Versatility: The assembly can be used with various separation techniques, such as liquid chromatography or capillary electrophoresis, making it adaptable to different analytical needs.
* Easy maintenance: The removable fitting and integrated stop facilitate easy cleaning and maintenance of the assembly, ensuring reliable and consistent performance.


==Original Abstract Submitted==

an electrospray emitter assembly for interfacing a separation column to a mass spectrometer is disclosed. an emitter capillary includes an inlet end and an outlet end. a fitting is coupled to the inlet end of the emitter, configured to be removably connected to the separation column. a stop with a defined through hole is integrated proximate the inlet end of the emitter to produce a path for liquid to flow from the separation column to the emitter via the through hole where a voltage is applied to the liquid entering the emitter.



[[Category:G01N30/72]]
[[Category:H01J49/04]]