View source for 18332430. ASSAYS FOR DETECTION OF ACUTE LYME DISEASE simplified abstract (THE REGENTS OF THE UNIVERSITY OF CALIFORNIA)

=ASSAYS FOR DETECTION OF ACUTE LYME DISEASE=


==Organization Name==

[[:Category:THE REGENTS OF THE UNIVERSITY OF CALIFORNIA|THE REGENTS OF THE UNIVERSITY OF CALIFORNIA]]


[[Category:THE REGENTS OF THE UNIVERSITY OF CALIFORNIA]]

==Inventor(s)==

[[:Category:Charles Y. Chiu of San Francisco CA (US)|Charles Y. Chiu of San Francisco CA (US)]][[Category:Charles Y. Chiu of San Francisco CA (US)]]

[[:Category:Jerome Bouquet of San Francisco CA (US)|Jerome Bouquet of San Francisco CA (US)]][[Category:Jerome Bouquet of San Francisco CA (US)]]

[[:Category:Mark J. Soloski of Baltimore MD (US)|Mark J. Soloski of Baltimore MD (US)]][[Category:Mark J. Soloski of Baltimore MD (US)]]

[[:Category:John N. Aucott of Lutherville MD (US)|John N. Aucott of Lutherville MD (US)]][[Category:John N. Aucott of Lutherville MD (US)]]

==ASSAYS FOR DETECTION OF ACUTE LYME DISEASE - A simplified explanation of the abstract==


This abstract first appeared for US patent application 18332430 titled 'ASSAYS FOR DETECTION OF ACUTE LYME DISEASE

==Simplified Explanation==

The patent application is about a method for determining whether a human subject has acute Lyme disease by analyzing the gene expression of cells in a blood sample. 

* The method involves measuring the gene expression of cells in a blood sample obtained from a mammalian subject suspected of having a tick-borne disease.
* Specifically, the method focuses on transcriptome profiling of peripheral blood mononuclear cells.
* The goal is to determine whether the subject has acute Lyme disease based on the gene expression patterns observed in the blood sample.

== Potential Applications ==
This technology has potential applications in the field of diagnosing tick-borne diseases, specifically acute Lyme disease.

* Medical diagnosis: The method can be used by healthcare professionals to accurately diagnose acute Lyme disease in human subjects.
* Treatment planning: The gene expression analysis can provide valuable information for developing personalized treatment plans for patients with acute Lyme disease.
* Research: The method can be used in research studies to better understand the gene expression patterns associated with tick-borne diseases.

== Problems Solved ==
This technology addresses several problems related to the diagnosis of acute Lyme disease.

* Early detection: The method allows for the early detection of acute Lyme disease, enabling prompt treatment and potentially preventing the progression of the disease.
* Accuracy: By analyzing the gene expression patterns, the method provides a more accurate diagnosis compared to traditional diagnostic methods, which may have limitations in sensitivity and specificity.
* Non-invasive: The method utilizes a blood sample, which is a non-invasive and easily accessible specimen, making it convenient for patients and healthcare providers.

== Benefits ==
The use of gene expression analysis for diagnosing acute Lyme disease offers several benefits.

* Improved accuracy: By analyzing gene expression patterns, the method provides a more accurate diagnosis, reducing the risk of misdiagnosis and ensuring appropriate treatment.
* Early intervention: Early detection of acute Lyme disease allows for timely intervention, potentially preventing the development of severe symptoms and complications.
* Personalized treatment: The gene expression analysis can provide insights into the specific molecular mechanisms involved in the disease, enabling personalized treatment plans tailored to individual patients.


==Original Abstract Submitted==

The present disclosure relates to measuring gene expression of cells of a blood sample obtained from a mammalian subject suspected of having a tick-borne disease. In particular, the present disclosure provides tools for determining whether a human subject has acute Lyme disease by transcriptome profiling a peripheral blood mononuclear cell sample from the subject.



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