BIOCHEMICAL REACTION TEMPERATURE REGULATOR WITH STABILIZED, SELF-REGULATING HEAT SOURCE

Abstract: the present disclosure is directed to a self-regulating temperature regulation system and related methods for regulating temperature during a biochemical reaction. the temperature regulation system includes: an expandable pouch comprising an inner cavity and a phase change material disposed within the inner cavity; a heat source comprising a pouch-facing side and an air-facing side, the pouch-facing side being in thermal contact with the pouch, the heat source being configured to generate heat upon activation and exposure to air and to cause phase change from liquid to gas of at least a portion of the phase change material; and a housing surrounding the heat source and pouch, the housing defining an air gap between the air-facing side of the heat source and an interior surface of the housing. the pouch is configured to expand as gas is generated within the inner cavity, thereby reducing the air gap and regulating air access to the heat source.

Inventor(s): Joshua R. BUSER, Daniel E. MORGAN

CPC Classification: B01L7/52 ({with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples (amplification or hybridisation processes per se ; controlling sequential reactions for synthesis )})

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