DETERMINING A TEMPERATURE OF A FIRST SHEET OF A WALL OF A POLYMERASE CHAIN REACTION (PCR) WELL BASED ON A RESISTANCE AND A CORRECTION MODEL

Abstract: a device includes a well and a control portion. the well is to receive a polymerase chain reaction (pcr) mixture within an interior partially defined by a first wall, which comprise a heating first sheet. the control portion is to determine a first temperature of a first portion of the first sheet exposed to the interior, based on monitoring a resistance of the first sheet and based on a correction model, the correction model representing a thermal behavior of at least one structure which further defines the well and which is in thermal relation with at least a second portion the first sheet. the control portion is also, based on the determined first temperature, to apply a first electrical signal to the heating first sheet to heat the pcr mixture, at a selectable temperature, within a thermal cycling zone within the interior in close thermal proximity to the first wall.

Inventor(s): Napoleon J. LEONI, Omer GILA

CPC Classification: B01L7/52 ({with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples (amplification or hybridisation processes per se ; controlling sequential reactions for synthesis )})

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