18578966. PREFUSION-STABILIZED CHIMERIC HMPV-RSV F PROTEINS simplified abstract (Board of Regents, The University of Texas System)

PREFUSION-STABILIZED CHIMERIC HMPV-RSV F PROTEINS

Organization Name

Board of Regents, The University of Texas System

Inventor(s)

Jason Mclellan of Austin TX (US)

Ching-Lin Hsieh of Austin TX (US)

PREFUSION-STABILIZED CHIMERIC HMPV-RSV F PROTEINS - A simplified explanation of the abstract

This abstract first appeared for US patent application 18578966 titled 'PREFUSION-STABILIZED CHIMERIC HMPV-RSV F PROTEINS

• • Simplified Explanation:**

The patent application discusses chimeric hMPV/RSV F proteins that show improved stability and expression. These proteins can be used in diagnostics, screening platforms, and vaccine compositions.

• • Key Features and Innovation:**
• Chimeric hMPV/RSV F proteins with enhanced stability and expression.
• Potential use in diagnostics, screening platforms, and vaccines.

• • Potential Applications:**

The technology can be applied in:

• Diagnostics for respiratory syncytial virus (RSV) and human metapneumovirus (hMPV).
• Screening platforms for drug discovery.
• Vaccine compositions for RSV and hMPV.

• • Problems Solved:**
• Addressing the need for stable and highly expressed F proteins for RSV and hMPV.
• Improving the efficacy of diagnostics and vaccines for these viruses.

• • Benefits:**
• Enhanced stability and expression of F proteins.
• Improved accuracy in diagnostics.
• Potential for more effective vaccines.

• • Commercial Applications:**
• Title: Enhanced Chimeric hMPV/RSV F Proteins for Diagnostics, Screening, and Vaccines
• The technology can be commercialized in the pharmaceutical industry for developing diagnostic kits, screening assays, and vaccine formulations for RSV and hMPV.

• • Questions about Chimeric hMPV/RSV F Proteins:**

1. What are the specific advantages of using chimeric hMPV/RSV F proteins in diagnostics and vaccines? 2. How do these chimeric proteins compare to traditional F proteins in terms of stability and expression levels?

Original Abstract Submitted

Provided herein are chimeric hMPV/RSV F proteins. In some aspects, the chimeric hMPV/RSV F proteins exhibit enhanced conformational stability, enhanced thermostability, and/or increased expression. Methods are also provided for use of the chimeric F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.