18250727. SILICASOME NANOCARRIER FOR METAL-BASED DRUG DELIVERY simplified abstract (THE REGENTS OF THE UNIVERSITY OF CALIFORNIA)

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SILICASOME NANOCARRIER FOR METAL-BASED DRUG DELIVERY

Organization Name

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor(s)

Andre E. Nel of Sherman Oaks CA (US)

Huan Meng of Los Angeles CA (US)

Xiangsheng Liu of Los Angeles CA (US)

SILICASOME NANOCARRIER FOR METAL-BASED DRUG DELIVERY - A simplified explanation of the abstract

This abstract first appeared for US patent application 18250727 titled 'SILICASOME NANOCARRIER FOR METAL-BASED DRUG DELIVERY

Simplified Explanation

The patent application describes drug delivery vehicles that contain metal-based therapeutic agents. These vehicles consist of silica nanoparticles with cavities, a metal-based chemotherapeutic drug, and a lipid bilayer that encapsulates the nanoparticle.

  • Drug delivery vehicles with metal-based therapeutic agents are provided.
  • The vehicles are made of silica nanoparticles with cavities.
  • The nanoparticles have an outside surface that is in fluid communication with the cavities.
  • The vehicles contain a metal-based chemotherapeutic drug, such as platinum-based drugs.
  • The drug is either on the surface of the nanoparticle or within the cavities.
  • The drug is cationic and metal-based.
  • The vehicles are sealed and encapsulated by a lipid bilayer.

Potential Applications

  • Targeted drug delivery for cancer treatment.
  • Enhanced efficacy of metal-based chemotherapeutic drugs.
  • Controlled release of drugs within the body.

Problems Solved

  • Improves the delivery and effectiveness of metal-based chemotherapeutic drugs.
  • Provides a targeted drug delivery system for specific cells or tissues.
  • Enhances drug stability and reduces side effects.

Benefits

  • Increased therapeutic efficacy of metal-based chemotherapeutic drugs.
  • Reduced toxicity and side effects.
  • Improved drug stability and controlled release.
  • Targeted delivery to specific cells or tissues.


Original Abstract Submitted

In various embodiments, drug delivery vehicles that contain one or more metal-based therapeutic agents are provided. In certain embodiments, the drug delivery vehicle comprises: a silica nanoparticle comprising one or more cavities disposed within the nanoparticle and an outside surface where the one or more cavities are in fluid communication with the outside surface of the nanoparticle; a metal-based (e.g., platinum-based) chemotherapeutic drug disposed on the surface of the nanoparticle and/or within the one or more cavities of the nanoparticle where the drug comprises a cationic, metal-based drug; and a lipid bilayer disposed on the surface of the nanoparticle where the lipid bilayer fully encapsulates and seals the nanoparticle.

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