18266085. SPATIAL GENOMICS WITH SINGLE CELL RESOLUTION simplified abstract (THE REGENTS OF THE UNIVERSITY OF CALIFORNIA)

SPATIAL GENOMICS WITH SINGLE CELL RESOLUTION

Organization Name

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor(s)

Cyrille L. Delley of Oakland CA (US)

Adam Abate of Oakland CA (US)

SPATIAL GENOMICS WITH SINGLE CELL RESOLUTION - A simplified explanation of the abstract

This abstract first appeared for US patent application 18266085 titled 'SPATIAL GENOMICS WITH SINGLE CELL RESOLUTION

Simplified Explanation

The present disclosure provides materials and methods for sequencing a tissue sample and that allows spatial information about the tissue to be recovered by sequencing approaches at a single cell level.

• This patent application focuses on sequencing a tissue sample to recover spatial information at a single cell level.
• The innovation involves developing materials and methods for this sequencing approach.
• The technology enables researchers to understand the spatial organization of cells within a tissue sample.
• By sequencing at a single cell level, this approach provides detailed information about the interactions and relationships between cells in the tissue.

Potential Applications

This technology could be applied in various fields such as:

• Cancer research to study tumor microenvironments.
• Developmental biology to understand tissue formation.
• Neurology to map neural circuits in the brain.

Problems Solved

This technology addresses the following issues:

• Lack of spatial information in traditional sequencing methods.
• Difficulty in understanding cell interactions within tissues.
• Limited resolution in studying complex tissue structures.

Benefits

The benefits of this technology include:

• Enhanced understanding of tissue organization.
• Detailed insights into cell-to-cell communication.
• Improved accuracy in studying tissue dynamics.

Potential Commercial Applications

This technology has potential commercial applications in:

• Biotechnology companies for drug development.
• Research institutions for biological studies.
• Clinical laboratories for diagnostic purposes.

Possible Prior Art

One possible prior art in this field is the use of spatial transcriptomics techniques to analyze gene expression patterns in tissues. However, the present innovation focuses on sequencing at a single cell level to recover spatial information.

How does this technology compare to existing spatial sequencing methods?

This article does not provide a direct comparison with other spatial sequencing techniques currently available in the market. Further research or a comparative study would be needed to evaluate the advantages and limitations of this new approach.

What are the potential limitations of sequencing at a single cell level for recovering spatial information in tissues?

The article does not discuss any potential drawbacks or challenges associated with sequencing at a single cell level. It would be important to investigate factors such as cost, time, and data analysis complexity to fully understand the practical implications of this technology.

Original Abstract Submitted

The present disclosure provides materials and methods for sequencing a tissue sample and that allows spatial information about the tissue to be recovered by sequencing approaches at a single cell level.