View source for 20240042440. METHODS FOR EVALUATING RHEOTAXIS QUALITY IN A SPERM-CONTAINING SAMPLE AND SYSTEMS THEREFOR simplified abstract (CORNELL UNIVERSITY)

=METHODS FOR EVALUATING RHEOTAXIS QUALITY IN A SPERM-CONTAINING SAMPLE AND SYSTEMS THEREFOR=


==Organization Name==

[[:Category:CORNELL UNIVERSITY|CORNELL UNIVERSITY]]


[[Category:CORNELL UNIVERSITY]]

==Inventor(s)==

[[:Category:Alireza Abbaspourrad of Ithaca NY (US)|Alireza Abbaspourrad of Ithaca NY (US)]][[Category:Alireza Abbaspourrad of Ithaca NY (US)]]

[[:Category:Mohammad Yaghoobi of Ithaca NY (US)|Mohammad Yaghoobi of Ithaca NY (US)]][[Category:Mohammad Yaghoobi of Ithaca NY (US)]]

[[:Category:Morteza Azizi of Ithaca NY (US)|Morteza Azizi of Ithaca NY (US)]][[Category:Morteza Azizi of Ithaca NY (US)]]

==METHODS FOR EVALUATING RHEOTAXIS QUALITY IN A SPERM-CONTAINING SAMPLE AND SYSTEMS THEREFOR - A simplified explanation of the abstract==


This abstract first appeared for US patent application 20240042440 titled 'METHODS FOR EVALUATING RHEOTAXIS QUALITY IN A SPERM-CONTAINING SAMPLE AND SYSTEMS THEREFOR

==Simplified Explanation==

The present technology is related to a system for quantifying rheotaxis in a sperm-containing sample. The system includes a microfluidic system with an inlet for charging fluids into a passage. Within the passage, there are one or more probes that define a confinement region suitable for retaining motile sperm. The system also includes an image processing computing device that obtains a sequence of images of the confinement region with motile sperm retained in at least one of the probes. The sequence of images is processed to determine a signal intensity value based on the concentration of motile sperm in the confinement region at the flow rate. A rheotaxis quality value is then determined for the sperm-containing sample based on the signal intensity value. Methods for quantifying rheotaxis in a sperm-containing sample are also disclosed.

* The system quantifies rheotaxis in a sperm-containing sample using a microfluidic system and image processing.
* The microfluidic system has an inlet for charging fluids and one or more probes that retain motile sperm in a confinement region.
* The image processing computing device obtains a sequence of images of the confinement region with motile sperm and determines a signal intensity value based on the concentration of sperm.
* A rheotaxis quality value is determined for the sperm-containing sample based on the signal intensity value.
* The technology provides a method for quantifying rheotaxis in a sperm-containing sample.

== Potential Applications ==
* Assisted reproductive technology: The technology can be used to assess the quality and viability of sperm in a sample, aiding in the selection of sperm for assisted reproductive procedures.
* Fertility research: The system can be utilized in research studies to investigate the rheotaxis behavior of sperm and its implications for fertility.
* Animal breeding: The technology can be applied in animal breeding programs to evaluate the quality of sperm samples and improve breeding success rates.

== Problems Solved ==
* Objective quantification of rheotaxis: The technology provides a standardized and objective method for quantifying the rheotaxis behavior of sperm, eliminating subjective assessments.
* Efficiency and accuracy: The microfluidic system and image processing allow for efficient and accurate analysis of sperm samples, reducing the time and effort required for manual assessments.
* Non-invasive analysis: The system enables non-invasive analysis of sperm samples, minimizing potential damage or alteration to the sperm.

== Benefits ==
* Improved reproductive outcomes: By accurately assessing the rheotaxis quality of sperm samples, the technology can help improve the success rates of assisted reproductive procedures.
* Enhanced fertility research: The system provides researchers with a reliable tool to study and understand the rheotaxis behavior of sperm, contributing to advancements in fertility research.
* Time and cost savings: The automated analysis provided by the technology reduces the need for manual assessments, saving time and resources in sperm analysis processes.


==Original Abstract Submitted==

the present technology relates to a systems for quantifying rheotaxis in a sperm-containing sample. the system includes a microfluidic system having an inlet for charging fluids into a passage. one or more probes defining a confinement region suitable for retaining motile sperm are within the passage. the system further comprises an image processing computing device for obtaining a sequence of images of the confinement region of at least one of the one or more probes having motile sperm retained therein. the sequence of images of the confinement region is processed to determine a signal intensity value for said sequence of images, wherein said signal intensity value is based on a concentration of the motile sperm located in the confinement region at the flow rate. a rheotaxis quality value is determined for said sperm-containing sample based on the signal intensity value. methods for quantifying rheotaxis in a sperm-containing sample are also disclosed.



[[Category:B01L3/00]]
[[Category:G06T7/00]]