View source for 20240041906. PRE-EXPOSURE PROPHYLAXIS OF HIV INFECTIONS simplified abstract (The U.S.A., as Represented by the Secretary, Department of Health and Human Services)

=PRE-EXPOSURE PROPHYLAXIS OF HIV INFECTIONS=


==Organization Name==

[[:Category:The U.S.A., as Represented by the Secretary, Department of Health and Human Services|The U.S.A., as Represented by the Secretary, Department of Health and Human Services]]


[[Category:The U.S.A., as Represented by the Secretary, Department of Health and Human Services]]

==Inventor(s)==

[[:Category:Walid Heneine of Atlanta GA (US)|Walid Heneine of Atlanta GA (US)]][[Category:Walid Heneine of Atlanta GA (US)]]

[[:Category:Thomas M. Folks of Helotes TX (US)|Thomas M. Folks of Helotes TX (US)]][[Category:Thomas M. Folks of Helotes TX (US)]]

[[:Category:Robert Janssen of Atlanta GA (US)|Robert Janssen of Atlanta GA (US)]][[Category:Robert Janssen of Atlanta GA (US)]]

[[:Category:Ronald A. Otten of Villa Rica GA (US)|Ronald A. Otten of Villa Rica GA (US)]][[Category:Ronald A. Otten of Villa Rica GA (US)]]

[[:Category:Jose Gerardo Garcia Lerma of Decatur GA (US)|Jose Gerardo Garcia Lerma of Decatur GA (US)]][[Category:Jose Gerardo Garcia Lerma of Decatur GA (US)]]

==PRE-EXPOSURE PROPHYLAXIS OF HIV INFECTIONS - A simplified explanation of the abstract==


This abstract first appeared for US patent application 20240041906 titled 'PRE-EXPOSURE PROPHYLAXIS OF HIV INFECTIONS

==Simplified Explanation==

The abstract describes a process for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. The process involves administering a combination of a nucleoside reverse transcriptase inhibitor and a nucleotide reverse transcriptase inhibitor to the primate host prior to exposure to the retrovirus. The administration can be done in a single dose within 24 hours of exposure or through regular daily doses. 

* The process involves administering a combination of two types of reverse transcriptase inhibitors to a primate host.
* The administration can be done in a single dose within 24 hours of exposure or through regular daily doses.
* The combination of inhibitors provides protection against the retrovirus becoming self-replicating after infecting the host.
* The process can also be used to control retrovirus transmission within a population by administering the combination to a high-risk subpopulation prior to sexual exposure to the retrovirus source.

Potential Applications:
* Prevention of immunodeficiency retroviral infections in primates.
* Control of retrovirus transmission within high-risk populations.

Problems Solved:
* Protection against self-replicating retroviral infections.
* Prevention of retrovirus transmission within populations.

Benefits:
* Effective protection can be achieved with a single dose or regular daily doses.
* Provides a method for controlling retrovirus transmission within high-risk populations.


==Original Abstract Submitted==

a process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. the administration is effective if provided in a single dose within 24 hours of the exposure. a regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. a process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation.



[[Category:A61K31/675]]
[[Category:A61K31/513]]
[[Category:A61K31/7072]]
[[Category:A61K45/06]]
[[Category:A61K31/683]]
[[Category:A61K9/00]]