View source for 20240009128. METHODS AND SYSTEMS FOR USE OF LOW-VOLATILITY SOLVENTS FOR SPRAY DRYING simplified abstract (Serán BioScience, LLC)

=METHODS AND SYSTEMS FOR USE OF LOW-VOLATILITY SOLVENTS FOR SPRAY DRYING=


==Organization Name==

[[:Category:Serán BioScience, LLC|Serán BioScience, LLC]]


[[Category:Serán BioScience, LLC]]

==Inventor(s)==

[[:Category:Mark Kastantin of Bend OR (US)|Mark Kastantin of Bend OR (US)]][[Category:Mark Kastantin of Bend OR (US)]]

[[:Category:Erica Schlesinger of Sisters OR (US)|Erica Schlesinger of Sisters OR (US)]][[Category:Erica Schlesinger of Sisters OR (US)]]

[[:Category:Dan Smithey of Bend OR (US)|Dan Smithey of Bend OR (US)]][[Category:Dan Smithey of Bend OR (US)]]

==METHODS AND SYSTEMS FOR USE OF LOW-VOLATILITY SOLVENTS FOR SPRAY DRYING - A simplified explanation of the abstract==


This abstract first appeared for US patent application 20240009128 titled 'METHODS AND SYSTEMS FOR USE OF LOW-VOLATILITY SOLVENTS FOR SPRAY DRYING

==Simplified Explanation==

The patent application describes pharmaceutical formulations, methods, and systems for spray drying pharmaceutical formulations. 

* The method involves selecting a solvent mixture with a low volatility solvent based on the solubility of the drug in the formulation. 
* A solution of the drug in the solvent mixture is formed. 
* The solution is then spray dried using a specific spray drying mass ratio, which is determined based on the relationship between the glass transition temperature of the formulation and the relative saturation of the low volatility solvent during spray drying. 
* The spray drying mass ratio defines the liquid feed rate of the solution to the gas feed rate of the drying gas. 
* The process outlet temperature is set to be lower than the glass transition temperature of the formulation.

Potential applications of this technology:
* This technology can be used in the pharmaceutical industry to produce dry powder formulations of drugs.
* It can be applied to various types of drugs, including those with low solubility in common solvents.
* The spray drying process allows for the production of fine particles, which can improve the bioavailability and stability of the drugs.
* The method can be used to produce pharmaceutical formulations with controlled release properties.

Problems solved by this technology:
* Spray drying is a commonly used technique in the pharmaceutical industry, but the selection of solvent mixtures and spray drying conditions can be challenging.
* This technology provides a systematic approach for selecting solvent mixtures and determining the spray drying mass ratio based on the properties of the drug formulation.
* It addresses the issue of low solubility of drugs by selecting solvent mixtures with low volatility solvents that can enhance drug solubility.

Benefits of this technology:
* The method allows for the production of dry powder formulations, which are easier to handle, store, and transport compared to liquid formulations.
* It provides a controlled and reproducible process for spray drying pharmaceutical formulations.
* The use of specific solvent mixtures and spray drying conditions can improve the solubility, bioavailability, and stability of drugs.
* The technology can be applied to a wide range of drugs, making it versatile in the pharmaceutical industry.


==Original Abstract Submitted==

pharmaceutical formulations, methods for spray drying pharmaceutical formations, and systems for spray drying pharmaceutical formulation are provided. in one example, a method for spray drying a pharmaceutical formulation may include selecting a solvent mixture comprising a low volatility solvent based on a solubility of a drug of the pharmaceutical formulation in the solvent mixture, forming a solution of the drug of the pharmaceutical formulation in the solvent mixture, and spray drying the solution using a spray drying mass ratio that is selected based on a relationship between a glass transition temperature of the pharmaceutical formulation and a relative saturation of the low volatility solvent during the spray drying, the spray drying mass ratio defining a liquid feed rate of the solution to a gas feed rate of a drying gas, and using a process outlet temperature that is less than the glass transition temperature of the pharmaceutical formulation.



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